Enol Tautomers of Watson−Crick Base Pair Models Are Metastable Because of Nuclear Quantum Effects.

Journal Of The American Chemical Society 132, 11510 - 11515 (2010)

Enol Tautomers of Watson−Crick Base Pair Models Are Metastable Because of Nuclear Quantum Effects.

Alejandro Perez, Mark E. Tuckerman, Harold P. Hjalmarson, O. Anatole von Lilienfeld

Intermolecular enol tautomers of Watson−Crick base pairs could emerge spontaneously via interbase double proton transfer. It has been hypothesized that their formation could be facilitated by thermal fluctuations and proton tunneling, and possibly be relevant to DNA damage. Theoretical and computational studies, assuming classical nuclei, have confirmed the dynamic stability of these rare tautomers. However, by accounting for nuclear quantum effects explicitly through Car−Parrinello path integral molecular dynamics calculations, we find the tautomeric enol form to be dynamically metastable, with lifetimes too insignificant to be implicated in DNA damage.

Additional Information

Doi
http://dx.doi.org/10.1021/ja102004b

Related Research Areas